Name: BPC-157 / TB-500- Lyophilized powder
Brand: Aeternum
Price: 111.0 USD
Availability: InStock

ANGIOGENIC SIGNALING

How BPC-157 upregulates VEGF and activates the VEGFR2 pathway, central mechanisms in the formation of new blood vessels.

CELLULAR MIGRATION

How actin-mediated mobility moves fibroblasts, keratinocytes, and endothelial cells through tissue - a prerequisite for regenerative processes across cellular systems.

NITRIC OXIDEMODULATION

How BPC-157 engages the nitric oxide pathway and its role in vascular signaling.

CYTOSKELETAL ORGANIZATION

How TB-500 sequesters G-actin to regulate cytoskeletal dynamics - the structural framework that governs cellular movement and division.

GROWTH FACTOR EXPRESSION

How BPC-157 influences the expression of FGF, EGF, and related growth factors involved in tissue signaling.

EXTRACELLULAR MATRIX REMODELING

How matrix metalloproteinase (MMP) signaling contributes to the reorganization of connective tissue during regenerative processes.

ANGIOGENIC SIGNALING

How BPC-157 upregulates VEGF and activates the VEGFR2 pathway, central mechanisms in the formation of new blood vessels.

CELLULAR MIGRATION

How actin-mediated mobility moves fibroblasts, keratinocytes, and endothelial cells through tissue - a prerequisite for regenerative processes across cellular systems.

NITRIC OXIDEMODULATION

How BPC-157 engages the nitric oxide pathway and its role in vascular signaling.

CYTOSKELETAL ORGANIZATION

How TB-500 sequesters G-actin to regulate cytoskeletal dynamics - the structural framework that governs cellular movement and division.

GROWTH FACTOR EXPRESSION

How BPC-157 influences the expression of FGF, EGF, and related growth factors involved in tissue signaling.

EXTRACELLULAR MATRIX REMODELING

How matrix metalloproteinase (MMP) signaling contributes to the reorganization of connective tissue during regenerative processes.

DISCOVER MORE

Designed in California. Sourced in Great Britain.

A transatlantic standard in peptide research.

Each batch of the BPC-157 + TB-500 blend is developed across two of the world's most rigorous research environments—combining US scientific design with British precision.

Designed in California
Sourced in Great Britain
Third-Party Purity Verification
Batch-Level Traceability

Format

20mg Research Blend

Classification

Complementary Peptide Blend

Purity

Third-Party Laboratory Tested

Sourcing

Designed in California. Sourced in Great Britain.

Documentation

Certificate of Analysis Available Upon Request

Before You Proceed

The BPC-157 + TB-500 blend is supplied exclusively as a research compound.

Please review the following carefully:

Not approved for human or veterinary use.

Not for human consumption.

Not intended for diagnosis, treatment or prevention of any condition.

No dosage or administration guidance is provided.

Handle only within appropriate research settings by trained professionals.

Scientific references reflect controlled laboratory research only.

IMPORTANT

Aeternum accepts no responsibility for any use of this compound outside its intended research application.

BPC-157 + TB-500 In Research

Among researchers, the BPC-157 + TB-500 pairing is one of the most recognizable in the field for the breadth of regenerative pathways it engages. The blend pairs two peptides developed from entirely different biological systems. BPC-157 is a fragment of a protective protein originally identified in human gastric juice¹. TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring cytoskeletal protein⁵ ⁶. The pairing engages two non-overlapping mechanisms: angiogenic signaling² ³ and actin-mediated cellular migration⁵ ⁷.

What Is BPC-157?

BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid peptide corresponding to a fragment of a protective protein originally identified in human gastric juice¹. Research focuses on its role in upregulating vascular endothelial growth factor (VEGF), modulating the nitric oxide pathway, and influencing the expression of growth factors involved in tissue signaling—including fibroblast growth factor (FGF) and epidermal growth factor (EGF)² ³ ⁴.

What Is TB-500?

TB-500 is a synthetic peptide fragment corresponding to the actin-binding region of thymosin beta-4, a naturally occurring protein involved in cytoskeletal regulation⁵ ⁶. Research focuses on its role in sequestering monomeric G-actin—the molecular building block of the cellular cytoskeleton to influence cell migration, motility, and the structural reorganization that underlies tissue remodeling⁵ ⁷ ⁸.

Curated Bio-Optimization Research

Aeternum curates research compounds for the study of cellular signaling, regenerative pathways, and the molecular systems at the foundation of longevity-led research.

Batch Traceability

Quality Over Scale

Dedicated Research Support

ABOUT US

Bio-Optimization Is the Pursuit

Of peak physical and mental performance through science-backed supplementation

Frequently Asked Questions

What is the BPC-157 +TB-500 blend?

The blend pairs two distinct synthetic peptides: BPC-157, a 15-amino-acid pentadecapeptide originally identified in human gastric juice, and TB-500, a synthetic fragment of the naturally occurring protein thymosin beta-4. Each is among the most extensively studied peptides in modern regenerative research, and together they are studied as a complementary pairing engaging two non-overlapping pathways.

Is the BPC-157 +TB-500 blend approved for humanuse?

No. The blend is not approved by the MHRA (UK), FDA (USA), or any other regulatory authority for human or veterinary use. Aeternum supplies this blend exclusively for research purposes. Not for human consumption.

Why are BPC-157 andTB-500 studied together?

Because their mechanisms are complementary rather than overlapping. BPC-157 is studied for its role in angiogenic signalling - the formation of new blood vessels - and growth factor expression. TB-500 is studied for its role in G-actin sequestration and cellular migration. One engages the signalling environment; the other engages the structural machinery of cellular movement. This is the scientific rationale for examining them as a blend.

What makes this blend different from a single-peptide compound?

Architecture. A single peptide engages one mechanism. This blend engages two through different cellular systems, with different downstream effects. BPC-157 contributes to angiogenic and growth factor signalling; TB-500 contributes to actin-mediated cellular migration. Together, they engage stages of the regenerative cascade that neither peptide engages alone.

Does Aeternum provide dosage guidance?

No. The blend supplied by Aeternum is intended strictly for lab research purposes by trained professionals only. We do not provide dosage recommendations, administration guidance, or medical advice.

What areas of research is the blend studied in?

Active areas of investigation include angiogenic signalling, cytoskeletal organization, cellular migration, growth factor expression, nitric oxide modulation, and extracellular matrix remodelling. These pathways are studied independently for each peptide and in combination as part of broader regenerative peptide research.

ASK A QUESTION

References

1

Sikiric P, Seiwerth S, Rucman R, et al. Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract. Current Pharmaceutical Design. 2011;17(16):1612–1632.
View Source
2

Hsieh MJ, Liu HT, Wang CN, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. Journal of Molecular Medicine. 2017;95(3):323–333.
View Source
3

Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, Seiwerth S. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Journal of Physiology and Pharmacology. 2009;60 Suppl 7:191–196.
View Source
4

Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066–19077.
View Source
5

Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends in Molecular Medicine. 2005;11(9):421–429.
View Source
6

Crockford D, Turjman N, Allan C, Angel J. Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications. Annals of the New York Academy of Sciences. 2010;1194:179–189
View Source
7

Malinda KM, Sidhu GS, Mani H, et al. Thymosin beta4 accelerates wound healing. Journal of Investigative Dermatology. 1999;113(3):364–368.
View Source
8

Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466–472.
View Source

Precision peptides. Elite standards. Designed for a higher standard of living.

Explore

SHOP

Links

STAY INFORMED

Exclusive insights on science, products, and protocols.

Website Developed by demo

BPC-157 / TB-500- Lyophilized powder

Safe & Secure Checkout

A Complementary Research Compound

ANGIOGENIC SIGNALING

CELLULAR MIGRATION

NITRIC OXIDEMODULATION

CYTOSKELETAL ORGANIZATION

GROWTH FACTOR EXPRESSION

EXTRACELLULAR MATRIX REMODELING

ANGIOGENIC SIGNALING

CELLULAR MIGRATION

NITRIC OXIDEMODULATION

CYTOSKELETAL ORGANIZATION

GROWTH FACTOR EXPRESSION

EXTRACELLULAR MATRIX REMODELING

Designed in California. Sourced in Great Britain.

Format

Classification

Purity

Sourcing

Documentation

Before You Proceed

BPC-157 + TB-500 In Research

What Is BPC-157?

What Is TB-500?

Curated Bio-Optimization Research

Bio-Optimization Is the Pursuit

Frequently Asked Questions

At the frontier of longevity science

NAD+Lyophilized powder

GHK-CU- Lyophilized powder