Name: GHK-CU- Lyophilized powder
Brand: Aeternum
Price: 111.0 USD
Availability: InStock

CONNECTIVE TISSUEBIOLOGY¹ ⁴

How copper delivery to lysyl oxidase contributes to collagen and elastin cross-linking, the foundational chemistry of extracellular matrix formation.

FIBROBLASTSIGNALING⁴ ⁵

How GHK-Cu engages TGF-β and PI3K/Akt pathways in fibroblast models, and the downstream effects on matrix protein synthesis.

MITOCHONDRIALFUNCTION² ⁵

How copper delivery to cytochrome c oxidase supports the electron transport chain and cellular energy metabolism.

ANTIOXIDANT ENZYME SUPPORT⁵

How GHK-Cu contributes to the activity of superoxide dismutase and other copper-dependent antioxidant enzymes involved in cellular redox balance.

TRANSCRIPTIONAL REGULATION³ ⁵ ⁷

How GHK-Cu modulates gene expression across thousands of human genes, shifting transcriptional signatures toward those characterized as regenerative.

INFLAMMATORY SIGNALING⁵ ⁶

How GHK-Cu influences pathways involved in pro-inflammatory cytokine expression, including TNF-α, IL-6, and NF-κB signaling.

CONNECTIVE TISSUEBIOLOGY¹ ⁴

How copper delivery to lysyl oxidase contributes to collagen and elastin cross-linking, the foundational chemistry of extracellular matrix formation.

FIBROBLASTSIGNALING⁴ ⁵

How GHK-Cu engages TGF-β and PI3K/Akt pathways in fibroblast models, and the downstream effects on matrix protein synthesis.

MITOCHONDRIALFUNCTION² ⁵

How copper delivery to cytochrome c oxidase supports the electron transport chain and cellular energy metabolism.

ANTIOXIDANT ENZYME SUPPORT⁵

How GHK-Cu contributes to the activity of superoxide dismutase and other copper-dependent antioxidant enzymes involved in cellular redox balance.

TRANSCRIPTIONAL REGULATION³ ⁵ ⁷

How GHK-Cu modulates gene expression across thousands of human genes, shifting transcriptional signatures toward those characterized as regenerative.

INFLAMMATORY SIGNALING⁵ ⁶

How GHK-Cu influences pathways involved in pro-inflammatory cytokine expression, including TNF-α, IL-6, and NF-κB signaling.

DISCOVER MORE

Designed in California, Sourced in Great Britain.

A transatlantic standard in peptide research.

Each batch of GHK-Cu is developed across two of the world's most rigorous research environments, combining US scientific design with British precision.

Designed in California
Sourced in Great Britain
Third-Party Purity Verification
Batch-Level Traceability

Format

50mg research peptide

Classification

Copper-binding tripeptide

Purity

Third-party laboratory tested

Sourcing

Designed in California. Sourced in Great Britain.

Documentation

Certificate of Analysis available upon request

Before You Proceed

GHK-Cu is supplied exclusively as a research compound.

Please review the following carefully:

Not approved for human or veterinary use.

Not for human consumption.

Not intended for diagnosis, treatment or prevention of any condition.

No dosage or administration guidance is provided.

Handle only within appropriate research settings by trained professionals.

Scientific references reflect controlled laboratory research only.

IMPORTANT

Aeternum accepts no responsibility for any use of this compound outside its intended research application.

GHK-Cu in Research

GHK-Cu is one of the most extensively studied peptides in modern science. First isolated from human plasma in 1973, it has remained a foundational research compound for over five decades, with renewed scientific attention following the publication of large-scale gene expression data showing modulation across thousands of human genes. What sustains the interest is the breadth of mechanisms. Where most peptides act through a single receptor, GHK-Cu is studied as a compound operating across three interconnected systems: copper transport, receptor-level signalling, and transcriptional regulation.

What Is GHK-Cu?

GHK-Cu is a naturally occurring tripeptide, glycyl-L-histidyl-L-lysine, bound to a copper(II) ion. It is present in human plasma and is released from tissue in response to injury, where it acts as a signalling molecule across multiple cellular systems. That breadth of activity is the defining feature of current research interest.
Copper transport and enzyme support² ¹
GHK-Cu binds copper with high affinity and delivers it to copper-dependent enzymes, including lysyl oxidase (involved in collagen and elastin cross-linking), superoxide dismutase (involved in antioxidant defence), and cytochrome c oxidase (involved in mitochondrial energy production).

Receptor-levelsignaling⁵

Beyond copper delivery, the peptide itself interacts with cell-surface receptors and integrins, activating downstream signalling cascades including the TGF-β pathway and PI3K/Akt axis in fibroblast models.
Gene expression modulation³ ⁵ ⁷
Large-scale transcriptomic analysis using the Broad Institute's Connectivity Map has characterized GHK-Cu as a broad gene expression modulator, with bidirectional effects across thousands of human genes, upregulating pathways associated with tissue repair and antioxidant defense while downregulating pathways associated with inflammation and tissue breakdown.

Curated Bio-Optimization Research

Aeternum curates research compounds for the study of cellular signaling, regenerative pathways, and the molecular systems at the foundation of longevity-led research.

Batch Traceability

Quality Over Scale

Dedicated Research Support

ABOUT US

Bio-Optimization Is the Pursuit

GHK-Cu reflects the research. Aeternum sets the standard.

Frequently Asked Questions

What is GHK-Cu?

GHK-Cu is a naturally occurring copper-binding tripeptide glycyl-L-histidyl-L-lysine bound to a copper(II) ion. First isolated from human plasma in 1973, it has been studied for over five decades and is one of the most extensively researched peptides in regenerative and cellular biology.

Is GHK-Cu approved for human use?

No. GHK-Cu is not approved by the MHRA (UK), FDA (US), or any other regulatory authority for human or veterinary use as a therapeutic compound. Aeternum supplies GHK-Cu research material exclusively for research purposes. Not for human consumption.

Why is GHK-Cu considered foundational?

Most research peptides act through a single mechanism. GHK-Cu is studied as a compound operating across three: copper delivery to copper-dependent enzymes, receptor-level signaling through pathways including TGF-β and PI3K/Akt, and broad modulation of gene expression. This multi-mechanism profile is unusual for a molecule of its size and is why it remains a model compound in modern peptide research.

What makes GHK-Cu different from other peptides?

Reach. Most peptides bind one receptor and trigger one downstream effect. GHK-Cu is studied as a compound that operates at three levels simultaneously, delivering copper to enzyme systems, engaging cell-surface signaling pathways, and modulating gene expression across thousands of human genes. This breadth of mechanism is what distinguishes it within peptide science. No. GHK-Cu supplied by Aeternum is intended strictly for research purposes only. We do not provide dosage recommendations, administration guidance, or medical advice. GHK-Cu is studied across an unusually broad range of scientific disciplines. Active areas of investigation include connective tissue biology, antioxidant enzyme support, fibroblast signaling, transcriptional regulation, inflammatory pathways, and mitochondrial function.

Does Aeternum provide dosage guidance?

No. GHK-Cu supplied by Aeternum is intended strictly for research purposes only. We do not provide dosage recommendations, administration guidance, or medical advice.

What areas of research is GHK-Cu studied in?

GHK-Cu is studied across an unusually broad range of scientific disciplines. Active areas of investigation include connective tissue biology, antioxidant enzyme support, fibroblast signaling, transcriptional regulation, inflammatory pathways, and mitochondrial function.

ASK A QUESTION

References

1

Pickart L. The human tri-peptide GHK and tissue remodeling. J Biomater Sci Polym Ed. 2008;19(8):969–988.
View Source
2

Pickart L, Freedman JH, Loker WJ, Peisach J, Perkins CM, Stenkamp RE, Weinstein B. Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells. Nature. 1980;288(5792):715–717.
View Source
3

Pickart L, Vasquez-Soltero JM, Margolina A. GHK and DNA: Resetting the Human Genome to Health. BioMed Research International. 2014;2014:151479.
View Source
4

Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066–19077.Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015;2015:648108.
View Source
5

Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences. 2018;19(7):1987.
View Source
6

Pickart L, Vasquez-Soltero JM, Margolina A. The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline. Brain Sciences. 2017;7(2):20.
View Source
7

Lamb J. The Connectivity Map: A new tool for biomedical research. Nature Reviews Cancer. 2007;7(1):54–60.
View Source
8

Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466–472.
View Source

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GHK-CU- Lyophilized powder

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A FoundationalResearch Compound

CONNECTIVE TISSUEBIOLOGY¹ ⁴

FIBROBLASTSIGNALING⁴ ⁵

MITOCHONDRIALFUNCTION² ⁵

ANTIOXIDANT ENZYME SUPPORT⁵

TRANSCRIPTIONAL REGULATION³ ⁵ ⁷

INFLAMMATORY SIGNALING⁵ ⁶

CONNECTIVE TISSUEBIOLOGY¹ ⁴

FIBROBLASTSIGNALING⁴ ⁵

MITOCHONDRIALFUNCTION² ⁵

ANTIOXIDANT ENZYME SUPPORT⁵

TRANSCRIPTIONAL REGULATION³ ⁵ ⁷

INFLAMMATORY SIGNALING⁵ ⁶

Designed in California, Sourced in Great Britain.

Format

Classification

Purity

Sourcing

Documentation

Before You Proceed

GHK-Cu in Research

What Is GHK-Cu?

Receptor-levelsignaling⁵

Curated Bio-Optimization Research

Bio-Optimization Is the Pursuit

Frequently Asked Questions

At the frontier of longevity science

NAD+Lyophilized powder