Name: NAD+Lyophilized powder
Brand: Aeternum
Price: 111.0 USD
Availability: InStock

MITOCHONDRIAL FUNCTION³ ⁷

How NAD+ availability influences electron transport chain capacity, oxidative phosphorylation efficiency, and mitochondrial energy output.

DNA REPAIR¹ ⁷

How PARP-mediated repair depends on NAD+ availability, and how NAD+ levels influence genomic stability over time.

NAD+ CONSUMPTION³ ⁴⁶

How CD38, PARPs, and sirtuins compete for the same NAD+ pool and how the balance between these enzyme families shapes cellular function.

SIRTUIN BIOLOGY¹ ² ⁵

How NAD-dependent sirtuin activity contributes to transcriptional regulation, mitochondrial maintenance, and cellular stress signalling.

MULTI-PATHWAY ROLE¹ ⁷

The defining feature: a single coenzyme required by three distinct enzyme families. Studied as a foundational regulatory variable rather than a single-target molecule.

REDOX SIGNALING⁷

How the NAD+/NADH ratio contributes to cellular redox balance and the regulation of metabolic pathways.

MITOCHONDRIAL FUNCTION³ ⁷

How NAD+ availability influences electron transport chain capacity, oxidative phosphorylation efficiency, and mitochondrial energy output.

DNA REPAIR¹ ⁷

How PARP-mediated repair depends on NAD+ availability, and how NAD+ levels influence genomic stability over time.

NAD+ CONSUMPTION³ ⁴⁶

How CD38, PARPs, and sirtuins compete for the same NAD+ pool and how the balance between these enzyme families shapes cellular function.

SIRTUIN BIOLOGY¹ ² ⁵

How NAD-dependent sirtuin activity contributes to transcriptional regulation, mitochondrial maintenance, and cellular stress signalling.

MULTI-PATHWAY ROLE¹ ⁷

The defining feature: a single coenzyme required by three distinct enzyme families. Studied as a foundational regulatory variable rather than a single-target molecule.

REDOX SIGNALING⁷

How the NAD+/NADH ratio contributes to cellular redox balance and the regulation of metabolic pathways.

DISCOVER MORE

Designed in California, Sourced in Great Britain.

A transatlantic standard in peptide research.

Each batch of NAD+ is developed across two of the world's most rigorous research environments, combining US scientific design with British precision.

Designed in California
Sourced in Great Britain
Third-Party Purity Verification
Batch-Level Traceability

Format

1000mg research compound

Classification

Cellular coenzyme

Purity

Third-party laboratory tested

Sourcing

Designed in California. Sourced in Great Britain.

Documentation

Certificate of Analysis available upon request

Before You Proceed

NAD+ is supplied exclusively as a research compound.

Please review the following carefully:

Not approved for human or veterinary use.

Not for human consumption.

Not intended for diagnosis, treatment or prevention of any condition.

No dosage or administration guidance is provided.

Handle only within appropriate research settings by trained professionals.

Scientific references reflect controlled laboratory research only.

IMPORTANT

Aeternum accepts no responsibility for any use of this compound outside its intended research application.

NAD+ in Research

NAD+ is one of the most extensively studied compounds in modern cellular biology¹ ⁷. Present in every living cell, it participates in hundreds of enzymatic reactions and sits at the intersection of three of the most active areas in longevity-led science: mitochondrial energy production, sirtuin biology¹ ² ⁵, and DNA repair¹ ⁷. What sustains the interest is its breadth of function. Where most cellular molecules serve a single role, NAD+ is studied as a coenzyme operating across three interconnected systems¹ ⁷ and its availability is increasingly understood as a central variable in cellular research³ ⁴.

What Is NAD+?

NAD+, nicotinamide adenine dinucleotide, is a naturally occurring coenzyme found in every living cell. Structurally, it is a dinucleotide composed of two linked nucleotides: one containing adenine, the other nicotinamide. Its function is unusually broad. Rather than acting on a single pathway, NAD+ serves as a required substrate or cofactor across three of the most fundamental systems in cellular biology.
Energy metabolism⁷
NAD+ acts as an electron carrier in glycolysis, the citric acid cycle, and mitochondrial oxidative phosphorylation. It is central to the chemistry through which cells generate ATP, the primary unit of cellular energy.

Sirtuin signaling¹ ² ⁵

NAD+ is the required substrate for the sirtuin enzyme family (SIRT1 through SIRT7), a group of NAD-dependent deacylases involved in transcriptional regulation, mitochondrial maintenance, and cellular stress signalling.
DNA repair¹ ⁷
NAD+ is the required substrate for poly(ADP-ribose) polymerases (PARPs), the enzyme family responsible for detecting DNA strand breaks and coordinating their repair.

Curated Bio-Optimization Research

Aeternum curates research compounds for the study of cellular signaling, regenerative pathways, and the molecular systems at the foundation of longevity-led research.

Batch Traceability

Quality Over Scale

Dedicated Research Support

ABOUT US

Bio-Optimization Is the Pursuit

NAD+ reflects the research. Aeternum sets the standard.

Frequently Asked Questions

What is NAD+?

NAD+, nicotinamide adenine dinucleotide, is a naturally occurring coenzyme found in every living cell. It is one of the most extensively studied molecules in cellular biology, participating in hundreds of enzymatic reactions across energy metabolism, gene regulation, and DNA repair.

Is NAD+ approved for human use?

No. NAD+ is not approved by the MHRA (UK), FDA (US), or any other regulatory authority for human or veterinary use as a therapeutic compound. Aeternum supplies NAD+ research material exclusively for research purposes.

Why is NAD+ considered foundational?

Most cellular molecules serve a single role. NAD+ serves three functions: it acts as an electron carrier in energy metabolism, as the required substrate for the sirtuin enzyme family, and as the required substrate for PARP enzymes in DNA repair. This breadth of function is why NAD+ remains a central focus of modern longevity-led research.

Is NAD+ a peptide?

No. NAD+ is a dinucleotide coenzyme, not a peptide. It is composed of two linked nucleotides, one containing adenine, the other nicotinamide. NAD+ is grouped within peptide research catalogues because it is studied alongside peptides in cellular optimization and longevity research, but its molecular classification is distinct.

Does Aeternum provide dosage guidance?

No. NAD+ supplied by Aeternum is intended strictly for research purposes only. We do not provide dosage recommendations, administration guidance, or medical advice.

What areas of research is NAD+ studied in?

NAD+ is studied across one of the broadest research landscapes in cellular biology. Active areas of investigation include mitochondrial function, sirtuin biology, DNA repair, NAD+ consumption dynamics (including the role of CD38), and the redox chemistry that underlies metabolic regulation.

ASK A QUESTION

References

1

Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464–471.
View Source
2

Imai S, Guarente L. It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging and Mechanisms of Disease. 2016;2:16017.
View Source
3

Camacho-Pereira J, Tarragó MG, Chini CCS, et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through a SIRT3-Dependent Mechanism. Cell Metabolism. 2016;23(6):1127–1139.
View Source
4

Chini CCS, Peclat TR, Warner GM, et al. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. Nature Metabolism. 2020;2(11):1284–1304.
View Source
5

Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000;403(6771):795–800.
View Source
6

Chini EN. CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions. Current Pharmaceutical Design. 2009;15(1):57–63.
View Source
7

Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208–1213.
View Source

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A FoundationalResearch Compound

MITOCHONDRIAL FUNCTION³ ⁷

DNA REPAIR¹ ⁷

NAD+ CONSUMPTION³ ⁴⁶

SIRTUIN BIOLOGY¹ ² ⁵

MULTI-PATHWAY ROLE¹ ⁷

REDOX SIGNALING⁷

MITOCHONDRIAL FUNCTION³ ⁷

DNA REPAIR¹ ⁷

NAD+ CONSUMPTION³ ⁴⁶

SIRTUIN BIOLOGY¹ ² ⁵

MULTI-PATHWAY ROLE¹ ⁷

REDOX SIGNALING⁷

Designed in California, Sourced in Great Britain.

Format

Classification

Purity

Sourcing

Documentation

Before You Proceed

NAD+ in Research

What Is NAD+?

Sirtuin signaling¹ ² ⁵

Curated Bio-Optimization Research

Bio-Optimization Is the Pursuit

Frequently Asked Questions

At the frontier of longevity science